Acetyl-L-carnitine for symptomatic diabetic neuropathy

Acetyl-L-carnitine for symptomatic diabetic neuropathy

Acetyl-L-carnitine for symptomatic diabetic neuropathy

Acetyl-L-carnitine for symptomatic diabetic neuropathy

Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding Worcester rat.

The abnormalities underlying diabetic neuropathy appear to be multiple and involve metabolic neuronal and vasomediated defects. The accumulation of long-chain fatty acids and impaired beta-oxidation due to deficiencies in carnitine and/or its esterified derivatives, such as acetyl-L-carnitine, may have deleterious effects. In the present study, we examined, in the diabetic bio-breeding Worceste...

The Effect of Acetyl-L-Carnitine on Learning and Spatial Memory Deficit in Diabetic Rats

Background & Aims: Diabetes mellitus is a chronic metabolic disorder that in the long-term is accompanied with deficits in learning, memory, and cognitive skills. Due to the existing evidence regarding the anti-diabetic potential of acetyl-L-carnitine (ALC), the effect of its long-term administration on learning and spatial memory deficits was investigated in diabetic rats. Methods: In this exp...